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●Highly efficient transfection Highly efficient RNA (siRNA, miRNA, mRNA, shRNA) transfection in a wide variety of cells including primary cells and suspension cells.

●Low Cellular Toxicity Transfection with serum, no need to add additional medium or replace the medium after transfection because of low cellular toxicity.

●High Knockdown Efficiency Many SCI papers proved. Here is part of the papers citing use of Engreen RNA transfection reagents.

  1. Biochim Biophys Acta Mol Basis Dis. 2019 Dec 1;1865(12):165540. doi: 10.1016/j.bbadis.2019.165540. Epub 2019 Aug 27.
    G-MDSC-derived exosomes attenuate collagen-induced arthritis by impairing Th1 and Th17 cell responses.

  2. Mol Ther Nucleic Acids. 2019 Sep 6;17:38-48. doi: 10.1016/j.omtn.2019.05.004. Epub 2019 May 22.
    Circular RNA Expression Profiling and the Potential Role of hsa_circ_0089172 in Hashimoto’s Thyroiditis via Sponging miR125a-3p.

  3. Biosci Rep. 2019 Aug 19;39(8). pii: BSR20190109. doi: 10.1042/BSR20190109. Print 2019 Aug 30.
    Liraglutide inhibits the apoptosis of human nucleus pulposus cells induced by high glucose through PI3K/Akt/caspase-3 signaling pathway.

  4. J Autoimmun. 2019 Aug;102:96-113. doi: 10.1016/j.jaut.2019.04.018. Epub 2019 May 23.
    NF-κB-driven miR-34a impairs Treg/Th17 balance via targeting Foxp3.

  5. Cancer Lett. 2019 May 28;450:110-122. doi: 10.1016/j.canlet.2019.02.029. Epub 2019 Feb 18.
    STAT3 inhibition enhances CDN-induced STING signaling and antitumor immunity.

  6. Chemosphere. 2019 May;223:165-170. doi: 10.1016/j.chemosphere.2019.01.169. Epub 2019 Feb 1.
    Polychlorinated diphenyl sulfides can induce ROS and genotoxicity via the AhR-CYP1A1 pathway.

  7. Leuk Lymphoma. 2019 Mar;60(3):772-781. doi: 10.1080/10428194.2018.1493727. Epub 2019 Jan 15.
    Targeting the cross-talk between the hedgehog and NF-κB signaling pathways in multiple myeloma.

  8. Mol Cancer. 2019 Mar 30;18(1):61. doi: 10.1186/s12943-019-0978-2.
    Long noncoding RNA Pvt1 regulates the immunosuppression activity of granulocytic myeloid-derived suppressor cells in tumor-bearing mice.

  9. Int J Mol Med. 2018 Jun;41(6):3379-3393. doi: 10.3892/ijmm.2018.3526. Epub 2018 Mar 1.
    MicroRNA-155 inhibits the osteogenic differentiation of mesenchymal stem cells induced by BMP9 via downregulation of BMP signaling pathway.

  10. J Virol. 2018 Apr 13;92(9). pii: e00033-18. doi: 10.1128/JVI.00033-18. Print 2018 May 1.
    Lactic acid downregulates viral microRNA to promote Epstein-Barr Virus-immortalized B lymphoblastic cell adhesion and growth.

  11. Mol Med Rep. 2018 Apr;17(4):5851-5859. doi: 10.3892/mmr.2018.8601. Epub 2018 Feb 13.
    Long non‑coding RNA BC168687 small interfering RNA reduces high glucose and high free fatty acid‑induced expression of P2X7 receptors in satellite glial cells.

  12. Biofactors. 2018 Mar;44(2):123-136. doi: 10.1002/biof.1395. Epub 2017 Nov 29.
    Dihydromyricetin inhibits NLRP3 inflammasome-dependent pyroptosis by activating the Nrf2 signaling pathway in vascular endothelial cells.

  13. Exp Cell Res. 2017 Dec 15;361(2):342-352. doi: 10.1016/j.yexcr.2017.11.002. Epub 2017 Nov 2.
    Erythropoietin ameliorates early brain injury after subarachnoid haemorrhage by modulating microglia polarization via the EPOR/JAK2-STAT3 pathway.

  14. J Cell Mol Med. 2017 Apr;21(4):802-815. doi: 10.1111/jcmm.13022. Epub 2016 Nov 25.
    A novel P53/POMC/Gαs/SASH1 autoregulatory feedback loop activates mutated SASH1 to cause pathologic hyperpigmentation.

  15. J Exp Clin Cancer Res. 2016 Sep 17;35(1):145. doi: 10.1186/s13046-016-0423-y.
    Demystifying the mechanistic and functional aspects of p21 gene activation with double-stranded RNAs in human cancer cells.

  16. J Orthop Translat. 2016 Jun 8;7:1-6. doi: 10.1016/j.jot.2016.05.011. eCollection 2016 Oct.
    Knockdown of asporin affects transforming growth factor-β1-induced matrix synthesis in human intervertebral annulus cells.

  17. Immunol Res. 2016 Apr;64(2):489-96. doi: 10.1007/s12026-015-8715-4.
    Upregulation of long noncoding RNA TMEVPG1 enhances T helper type 1 cell response in patients with Sjögren syndrome.

  18. Stem Cells Dev. 2016 Mar 15;25(6):477-91. doi: 10.1089/scd.2015.0301. Epub 2016 Feb 22.
    High-Efficient Transfection of Human Embryonic Stem Cells by Single-Cell Plating and Starvation.

  19. Mol Med Rep. 2016 Mar;13(3):2492-8. doi: 10.3892/mmr.2016.4814. Epub 2016 Jan 27.
    Downregulated microRNA-23b promotes BMP9-mediated osteogenesis in C2C12 myoblast cells by targeting Runx2.

  20. Int J Mol Med. 2015 Dec;36(6):1497-506. doi: 10.3892/ijmm.2015.2363. Epub 2015 Oct 9.
    miR-21 synergizes with BMP9 in osteogenic differentiation by activating the BMP9/Smad signaling pathway in murine multilineage cells.

  21. Mol Biosyst. 2015 Nov;11(11):3040-7. doi: 10.1039/c5mb00347d.
    The involvement of aquaporin 1 in the hepatopulmonary syndrome rat serum-induced migration of pulmonary arterial smooth muscle cells via the p38-MAPK pathway.

  22. Tumour Biol. 2016 Mar;37(3):3479-88. doi: 10.1007/s13277-015-4086-7. Epub 2015 Oct 9.
    MiR-30a regulates the proliferation, migration, and invasion of human osteosarcoma by targeting Runx2.

  23. Endocrine. 2015 Aug;49(3):752-60. doi: 10.1007/s12020-015-0546-5. Epub 2015 Feb 11.
    MiR-346 regulates CD4⁺CXCR5⁺ T cells in the pathogenesis of Graves’ disease.

  24. J Immunol. 2015 Aug 1;195(3):1301-11. doi: 10.4049/jimmunol.1500209. Epub 2015 Jun 19.
    MicroRNA-9 Regulates the Differentiation and Function of Myeloid-Derived Suppressor Cells via Targeting Runx1.

  25. Immunol Res. 2015 Jun;62(2):129-36. doi: 10.1007/s12026-015-8643-3.
    Decreased expression of microRNA-125a-3p upregulates interleukin-23 receptor in patients with Hashimoto’s thyroiditis.

  26. PLoS One. 2015 Mar 31;10(3):e0121510. doi: 10.1371/journal.pone.0121510. eCollection 2015.
    MicroRNA-22 impairs anti-tumor ability of dendritic cells by targeting p38.

  27. Apoptosis. 2015 Jan;20(1):92-109. doi: 10.1007/s10495-014-1058-0.
    RIP1-dependent Bid cleavage mediates TNFα-induced but Caspase-3-independent cell death in L929 fibroblastoma cells.

  28. Mol Biosyst. 2014 Apr;10(4):759-66. doi: 10.1039/c3mb70391f. Epub 2014 Jan 23.
    Paxillin suppresses the proliferation of HPS rat serum treated PASMCs by up-regulating the expression of cytoskeletal proteins.

  29. Apoptosis. 2013 Nov;18(11):1348-1362. doi: 10.1007/s10495-013-0866-y.
    The histone deacetylase inhibitor vorinostat prevents TNFα-induced necroptosis by regulating multiple signaling pathways.

  30. Cell Signal. 2013 Jun;25(6):1526-38. doi: 10.1016/j.cellsig.2012.12.025. Epub 2013 Jan 16.
    SASH1 regulates melanocyte transepithelial migration through a novel Gαs-SASH1-IQGAP1-E-Cadherin dependent pathway.

  31. J Immunol. 2013 Mar 1;190(5):2437-46. doi: 10.4049/jimmunol.1202282. Epub 2013 Jan 25.
    Multiple tumor-associated microRNAs modulate the survival and longevity of dendritic cells by targeting YWHAZ and Bcl2 signaling pathways.

  32. Respir Physiol Neurobiol. 2013 Jan 15;185(2):332-8. doi: 10.1016/j.resp.2012.09.009. Epub 2012 Oct 8.
    Effect of annexin A2 on hepatopulmonary syndrome rat serum-induced proliferation of pulmonary arterial smooth muscle cells.

  33. Genes Immun. 2012 Dec;13(8):621-31. doi: 10.1038/gene.2012.45. Epub 2012 Oct 4.
    TGF-β-associated miR-27a inhibits dendritic cell-mediated differentiation of Th1 and Th17 cells by TAB3, p38 MAPK, MAP2K4 and MAP2K7.

  34. Cytokine. 2012 Nov;60(2):505-13. doi: 10.1016/j.cyto.2012.06.317. Epub 2012 Jul 31.
    BLyS expression and JNK activation may form a feedback loop to promote survival and proliferation of multiple myeloma cells.

  35. Biochem J. 2012 Nov 1;447(3):407-16. doi: 10.1042/BJ20120256.
    Promoter-associated small double-stranded RNA interacts with heterogeneous nuclear ribonucleoprotein A2/B1 to induce transcriptional activation.

  36. J Cell Sci. 2012 Sep 15;125(Pt 18):4219-29. doi: 10.1242/jcs.086553. Epub 2012 May 28.
    Regulation of apoptosis by Bat3-enhanced YWK-II/APLP2 protein stability.

  37. J Radiat Res. 2012 Jul;53(4):516-25. doi: 10.1093/jrr/rrs002. Epub 2012 Jun 6.
    MicroRNA-148b enhances the radiosensitivity of non-Hodgkin’s Lymphoma cells by promoting radiation-induced apoptosis.

  38. Genes Immun. 2012 Jun;13(4):311-20. doi: 10.1038/gene.2011.87. Epub 2012 Jan 26.
    Global mapping of H3K4me3 and H3K27me3 reveals chromatin state-based regulation of human monocyte-derived dendritic cells in different environments.

  39. Cell Biochem Funct. 2012 Mar;30(2):108-13. doi: 10.1002/cbf.1823. Epub 2011 Oct 26.
    The effects of myocyte enhancer factor 2A gene on the proliferation, migration and phenotype of vascular smooth muscle cells.

  40. Virus Res. 2012 Jan;163(1):183-9. doi: 10.1016/j.virusres.2011.09.016. Epub 2011 Sep 16.
    Small interfering RNA against the 2C genomic region of coxsackievirus B3 exerts potential antiviral effects in permissive HeLa cells.

  41. J Sex Med. 2011 Oct;8(10):2773-80. doi: 10.1111/j.1743-6109.2011.02412.x. Epub 2011 Aug 5.
    Up-regulation of VEGF by small activator RNA in human corpus cavernosum smooth muscle cells.

  42. J Immunol. 2011 Apr 15;186(8):4716-24. doi: 10.4049/jimmunol.1002989. Epub 2011 Mar 7.
    Both miR-17-5p and miR-20a alleviate suppressive potential of myeloid-derived suppressor cells by modulating STAT3 expression.

  43. Microvasc Res. 2010 Jul;80(1):158-65. doi: 10.1016/j.mvr.2010.01.003. Epub 2010 Jan 14.
    A PKC-beta inhibitor treatment reverses cardiac microvascular barrier dysfunction in diabetic rats.

  44. Apoptosis. 2010 Apr;15(4):488-98. doi: 10.1007/s10495-009-0439-2.
    A PKC-beta inhibitor protects against cardiac microvascular ischemia reperfusion injury in diabetic rats.

  45. J Biol Chem. 2010 Apr 2;285(14):10890-901. doi: 10.1074/jbc.M109.058347. Epub 2010 Jan 26.
    Xenopus skip modulates Wnt/beta-catenin signaling and functions in neural crest induction.


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