CNS Neurosci Ther . 2018 Oct;24(10):906-916. doi: 10.1111/cns.12833. Epub 2018 Feb 27.

Inhibition of Lats1/p-YAP1 pathway mitigates neuronal apoptosis and neurological deficits in a rat model of traumatic brain injury

Di Li  1 Jia-Xuan Ji  2 Yi-Tian Xu  3 Hai-Bo Ni  4 Qin Rui  5 Hui-Xiang Liu  4 Feng Jiang  4 Rong Gao  4 Gang Chen  6

Affiliations

  • 1 Department of Neurosurgery and Translational Medicine Center, The First People’s Hospital of Zhangjiagang, Soochow University, Suzhou, China.
  • 2 Department of Neurosurgery, Zhangjiagang Hospital of Traditional Chinese Medicine, Nanjing University of Chinese Medicine, Suzhou, China.
  • 3 School of Basic Medical Sciences, Nanjing Medical University, Nanjing, China.
  • 4 Department of Neurosurgery, The First People’s Hospital of Zhangjiagang, Soochow University, Suzhou, China.
  • 5 Clinical laboratory, The First People’s Hospital of Zhangjiagang, Soochow University, Suzhou, China.
  • 6 Department of Neurosurgery, The First Affiliated Hospital of Soochow University, Suzhou, China.

Abstract

Aims: To investigate the roles of Lats1/p-YAP1 pathway in TBI-induced neuronal apoptosis and neurological deficits in rats.

Results: We found that Lats1 and YAP1 were expressed in cerebral cortex neurons of Sprague-Dawley rats, and the phosphorylation levels of Lats1 and YAP1 in injured regions were significantly increased after TBI. Furthermore, inhibition of Lats1 not only decreased the level of p-YAP1, but also attenuated neuronal apoptosis and neurological impairment.

Conclusions: Our work demonstrates that inhibition of Lats1/p-YAP1 pathway mitigates neuronal apoptosis and neurological deficits in a rat model of TBI.

Keywords: Lats1; YAP1; neurological deficit; neuronal apoptosis; traumatic brain injury.

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